What is Simparica TRIO?

Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Simparica TRIO requires a prescription from your veterinarian.

For:

Dogs and Puppies (8 weeks of age or older, weighing 2.8 lbs or more)

Benefits:

• Protects dogs against heartworm disease, ticks & fleas, roundworms & hookworms
• Tasty chewable that dogs love
• Convenient, once-a-month dosing

How does Simparica TRIO work?

Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.

Cautions:

Sarolaner, one of the ingredients in Simparica TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
Prior to administration of Simparica TRIO, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica TRIO is not effective against adult D. immitis. The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs.

Brand Name:

Simparica TRIO (Zoetis)